Rehabilitation interventions are often delivered in a one-size-fits-all manner. In studying gait retraining interventions for knee osteoarthritis, we have found it imperative to use a precision medicine approach. We design personalized interventions, deploy them with mobile devices (wearables or video), and test them in clinical trials. These devices fill a critical gap in musculoskeletal healthcare—reducing pain and restoring function without surgery.
Key Publications
Uhlrich S.D.*, Mazzoli V.*, Silder A., Finlay A.K., Kogan F., Gold G.E., Delp S.L., Beaupre G.S., Kolesar J.A., 2025. Personalised gait retraining for medial compartment knee osteoarthritis: a randomised controlled trial. Lancet Rheumatology, Published online August 12, 2025. *contributed equally. Download PDF of Accepted Manuscript, Supplementary Appendix. Media: Washington Post and Good Morning America.
Uhlrich S.D., Jackson R.W., Seth A., Kolesar J.A., Delp S.L., 2022. Muscle coordination retraining inspired by musculoskeletal simulations reduces knee contact force. Scientific Reports, 12(3):9842. Paper, News Story and Video
Uhlrich S.D., Kolesar J.A., Kidziński L., Boswell M.A., Silder A., Gold G.E., Delp S.L., Beaupre G.S., 2022. Personalization improves the biomechanical efficacy of foot progression angle modifications in individuals with medial knee osteoarthritis. Journal of Biomechanics, 144:111312. Download PDF
Uhlrich S.D., Silder A., Beaupré G.S. Shull, P.B. Delp, S.L., 2018. Subject-specific toe-in or toe-out gait modifications reduce the larger knee adduction moment peak more than a non-personalized approach. Journal of Biomechanics , 66:p103-110. Download PDF