We investigate the interplay between tissue mechanics and damage/remodeling. This includes examining the effects of acute bone loading on bone remodeling using PET-MRI and studying how altered cartilage loading affects cartilage microstructural health in osteoarthritis via quantitative MRI.
An example project (left) combines finite element modeling with PET-MR to examine how bone strains relate to changes in metabolic activity after exercise.
Representative Publications
Watkins L., MacKay J., Haddock B., Mazzoli V., Uhlrich S.D., Gold G.E., Kogan F., 2021. Assessment of quantitative [18F] Sodium fluoride PET measures of knee subchondral bone perfusion and mineralization in osteoarthritic and healthy subjects. Osteoarthritis and Cartilage 29(6):849–858. Download PDF
Haddock B., Fan A.P., Uhlrich S.D., Jorgensen N., Suetta C., Gold G.E., Kogan F., 2019. Assessment of acute bone loading in humans using [18F]NaF PET/MRI. European Journal of Nuclear Medicine and Molecular Imaging 46(12):2452–2463. Download PDF
Collaborators
Garry Gold, Stanford University
Valentina Mazzoli, New York University
